Metastatic Testicular Mixed Germ Cell Tumors. A Diagnostic Dilemma in Cytology

نویسنده

  • Jyothi A Raj
چکیده

Germ cell tumours (GCTs) are the most common malignant tumours of the testes. Metastasis to cervical lymph nodes as the initial manifestation is rare. Mixed GCTs are a diagnostic challenge to the pathologist, particularly in cytology because of their histologic diversity; more so when they occur at unexpected sites, with unknown primary. Two young adult males presented with enlarged cervical lymph nodes. Fine needle aspiration cytology (FNAC) was reported as metastatic undifferentiated carcinoma, suspected to be arising from testis. Subsequently, left testes were found to be enlarged in both; histopathological examination confirmed mixed GCT. GCTs are important differential diagnoses for metastatic undifferentiated carcinomas in cervical lymph nodes in young adult males. A reliable diagnosis can be made on cytology, even in those patients in whom the primary is not known. This study aims to highlight the cytologic hallmarks of metastatic mixed GCT to arrive at an accurate diagnosis.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

فراوانی بروز مارکر گلیپیکان 3 (GPC3) در تومورهای سلول زایای بیضه

Background and purpose: Germ cell tumor is the most common malignancy of men between 15-34 years of age. Proper treatment is highly dependent on accurate histologic diagnosis, and different markers such as cytokeratin, CD3, GPC3 and etc. were proposed. It was reported that GPC3 is over expressed in testicular germ cell tumors by micro array assay. The aim of this study was to evaluate the expre...

متن کامل

C-Kit and Bcl-2 Expression in Testicular Cancer

Alterations of C-Kit and Bcl-2 have been shown to play important roles in many types of human cancers. Although there are emerging studies of C-Kit in testicular cancer biology, the significance of Bcl-2 in testicular neoplasms has not been well understood. We studied C-Kit and Bcl-2 expressions by immunohistochemistry in 18 testicular cancers including 8 seminomas, 7 mixed germ cell tumors, 1 ...

متن کامل

Bilateral Synchronous Testis Tumors of Different Histology: A Case Report

Background: Bilateral synchronous testis germ cell tumors with different histopathology are not common. Case Presentation: Here, a case of 27-year-old male who is reported presented with bilateral testicular swellings. There was a high α-fetoprotein level with bilateral lesions on scrotal USG. Bilateral orchiectomy was performed. According to pathology report, there was a right testicular semi...

متن کامل

Canine testicular tumors: two types of seminomas can be differentiated by immunohistochemistry

BACKGROUND Testicular tumors are the most common genital neoplasms in male dogs, with Leydig cell tumors (LCT), seminomas (SEM), and Sertoli cell tumors (SCT) the most common forms. Human SEM are classified as classical (CSEM) or spermatocytic (SSEM). Intratubular germ cell neoplasia of undifferentiated origin (IGCNU) is another form of human testicular tumor. The aim of this study was to verif...

متن کامل

Survival of Children with Germ Cell Tumors in Ali Asghar Hospital since 1990 to 2003

Background and Objective: Germ cell tumor (GCT) accounts for approximately 2-3% of all malignancies in children. In this respect, about 20% of patients with GCT are still resistant to therapy. Materials and Methods: The cross-sectional strategy of this survey was undertaken on 57 patients with germ cell ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2013